产品说明

一般描述

Apolipoprotein B mRNA editing catalytic polypeptide-like 3B (APOBEC3B) is expressed in tissue-specific manner. It has two zinc (Z)-coordinating deaminase domains. APOBEC3B is mapped to human chromosome 22q13.1. It belongs to cytidine deaminases family.

免疫原

apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B

应用

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.

生化/生理作用

Apolipoprotein B mRNA editing catalytic polypeptide-like 3B (APOBEC3B) incorporates cytidine (C) to uridine (U) in mRNA and cytidine to thymidine mutations single stranded DNA. It interacts with core proteins of human immunodeficiency virus and hepatitis B virus and alters their genome during reverse transcription process. APOBEC3B is highly expressed in breast, lung, bladder, cervix and lung carcinomas. Uracil lesion generation by APOBEC3B is considered as major contributor of mutations in various cancers.

特点和优势

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

联系

Corresponding Antigen APREST90188.

外形

Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.

法律信息

Prestige Antibodies is a registered trademark of sigma-aldrich Co. LLC

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