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Anti-APP (N-terminal region) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB4200536
规格纯度
IgG fraction of antiserum
参考价格
6453.87 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-APP (N-terminal region) antibody produced in rabbit
Anti-APPI
Anti-AD1
Anti-ABETA
Anti-ABPP
Anti-amyloid beta A4 protein precursor, AAA
Anti-CVAP
Anti-CTFgamma
Anti-PN2
Anti-PN-II
产品介绍:

产品说明

一般描述

Amyloid precursor protein (APP) is encoded by the gene mapped to human chromosome 21. It is a transmembrane glycoprotein widely distributed in many tissues. APP exists as multiple isoforms (100-140 kDa) including APP695, APP751 and APP770 that are derived from alternative mRNA splicing.

免疫原

synthetic peptide corresponding to an N-terminal region of human Amyloid Precursor Protein (APP), conjugated to KLH. The corresponding sequence is highly conserved (single amino acid substitution) in rat and mouse APP.

应用

Anti-APP (N-terminal region) antibody produced in rabbit has been used in:

  • immunoblotting
  • immunofluorescence
  • immunohistochemistry

生化/生理作用

The amyloid precursor protein (APP) undergoes extensive post-translational modifications including phosphorylation, glycosylation, tyrosine sulfation and nitration. APP has been reported to be phosphorylated at several sites that may affect its processing and secretion. Phosphorylation of APP at Thr688 by cyclin-dependent kinase 5 (Cdk5) has been shown to play a critical role in the proteolytic cleavage of APP. APP Thr688, phosphorylated form is found in the adult brain and it correlates with neuronal differentiation. Mutations in the APP gene are linked with rare forms of autosomal dominant familial Alzheimer′s disease (FAD). These mutations result in increased production of Aβ indicating a central role of Aβ peptide in the neuropathology of AD.

外形

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

产品性质

生物来源rabbit
偶联物unconjugated
抗体形式IgG fraction of antiserum
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
分子量antigen ~130 kDa
species reactivityhuman, rat, mouse
technique(s)indirect immunofluorescence: 1:250-1:500 using SH-SY5Y cells.
western blot: 1:1,000 using lysates of rat and mouse brain (S1 fraction)
UniProt登记号P05067
运输dry ice
储存温度−20℃
Gene Informationhuman ... APP(351)
mouse ... App(11820)
rat ... App(54226)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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