产品说明
一般描述
ADP ribosylation factor guanine nucleotide exchange factor 2 (ARFGEF2) possesses a Sec7 domain which is crucial for its activity. This protein is expressed in the brain and the gene encoding it is localized on human chromosome 20.
特异性
The antibody detects endogenous levels of total ARFGEF2 protein.
免疫原
Synthetic peptide corresponding to a region derived from internal residues of human ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
生化/生理作用
ADP ribosylation factor guanine nucleotide exchange factor 2 (ARFGEF2) activates ADP-ribosylation factors (ARFs) by exchanging guanosine diphosphate (GDP) with guanosine triphosphate (GTP). It aids in the release of type I tumor necrosis factor receptor (TNFR1) from human umbilical vein endothelial cells. Mutation in the ARFGEF2 gene has been linked to microcephaly and periventricular heterotopia.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | 202 kDa |
| species reactivity | mouse, human |
| 浓度 | 3.4 mg/mL |
| technique(s) | immunohistochemistry: 1:50- 1:200 western blot: 1:200-1:1000 (Cell Lysate) |
| 同位素/亚型 | IgG |
| 登记号 | NP_006411.2 |
| UniProt登记号 | Q9Y6D5 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... ARFGEF2(10564) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
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