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Anti-Aspa/Nur7 Antibody

品牌
Sigma-Aldrich
货号
ABN1698
规格纯度
from rabbit, purified by affinity chromatography
参考价格
5352.52 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-Aspa/Nur7 Antibody
Aspartoacylase, Aminoacylase-2, ACY-2, Aspa/Nur7, Anti-Aspartoacylase
产品介绍:

产品说明

一般描述

Aspartoacylase (EC 3.5.1.15; UniProt Q8R3P0; also known as Acy-2, Aminoacylase-2, Nur-7) is encoded by the Aspa (also known as Acy2) gene (Gene ID 11484) in murine species. Aspartoacylase catalyzes the deacetylation of N-acetylaspartate (NAA) to generate free acetate in the central nervous system (CNS). Mutations in the ASPA gene cause the autosomal recessive neurodegenerative Canavan disease (CD) that results in inadequate lipid/myelin synthesis during development. Immunohistochemical staining reveals that aspartoacylase colocalizes with the oligodendrocyte marker CC1 throughout the brain, indicating its role in myelination.

免疫原

N-terminally his-tagged full-length recombinant mouse Aspa/Nur7.

应用

Immunohistochemistry Analysis: A representative lot detected Aspa/Nur7-positive oligodendrocytes in corpus callosum/external capsule using free-floating mouse brain sections (Courtesy of Dr. John R. Moffett, Uniformed Services University of the Health Sciences).
Western Blotting Analysis: A representative lot detected Aspa/Nur7 in the cytosol, but not myelin, fraction from rat brain tissue homogenate (Madhavarao, C.N., et al. (2004). J Comp Neurol. 472(3):318-329).
Immunohistochemistry Analysis: A representative lot detected Aspa/Nur7 expression pattern in various regions of rat forebrain, including corpus callosum, cerebral cortex, hippocampal commissure (hc), fimbria, and anterior commissure (Madhavarao, C.N., et al. (2004). J Comp Neurol. 472(3):318-329).
Immunohistochemistry Analysis: A representative lot detected similar Aspa/Nur7 expression pattern as CC1 in various regions of rat forebrain, including the Purkinjie & axonal fiber layers of cerebellum, corpus callosum, as well as layer 2 of primary somatosensory cortex (Madhavarao, C.N., et al. (2004). J Comp Neurol. 472(3):318-329).
Research Category
Neuroscience
This Anti-Aspa/Nur7 Antibody is validated for use in Western Blotting, Immunohistochemistry for the detection of Aspa/Nur7.
Research Sub Category
Developmental Signaling

质量

Evaluated by Western Blotting in rat brain tissue lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected Aspa/Nur7 in 10 µg of rat brain tissue lysate.

目标描述

~37 kDa observed

外形

Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Protein G Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to lot specific datasheet.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss32160702
NACRESNA.41

产品性质

生物来源rabbit
质量水平100
抗体形式purified antibody
antibody product typeprimary antibodies
克隆polyclonal
纯化方式affinity chromatography
species reactivityrat, human, mouse
technique(s)immunohistochemistry: suitable
western blot: suitable
NCBI登记号NP_075602
UniProt登记号Q8R3P0
运输wet ice

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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