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位置:首页 > 品牌 > Sigma-Aldrich > Anti-Astrocytomas Antibody, a marker for Low Grade Astrocytoma, clone J1-31

Anti-Astrocytomas Antibody, a marker for Low Grade Astrocytoma, clone J1-31

品牌
Sigma-Aldrich
货号
MAB5372
规格纯度
ascites fluid, clone J1-31, Chemicon®
参考价格
5180.56 *本价格含增值税费
促销
服务
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  • 增值税票
数量
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产品名称:
Anti-Astrocytomas Antibody, a marker for Low Grade Astrocytoma, clone J1-31
产品介绍:

产品说明

特异性

The antibody recognizes an intracellular protein antigen (MW 30 kDa) expressed by human and rat astrocytes and other specialized glia (Muller cells of the retina, Bergmann fibers of the cerebellar cortex, tanycytes of the hypothalamus and ciliated ependymal cells) in the central nervous system (CNS).The antibody has recently been found to be a specific marker for low grade astrocytoma in human brain tissue. The antibody is able to distinguish between low grade astrocytoma and normal reactive gliosis (patent application filed).

Monoclonal antibody J1-31 was raised against crude homogenate of brain tissue from a multiple sclerosis (MS) patient (autopsy sample; Malhotra et al.: Microbios Letters 26:151-157, 1984). In human brain, MAb J1-31 recognizes an intracellular protein antigen (J1-31 antigen), which bands at approximately 30,000 daltons under reducing conditions for sodium dodecyl sulfate gel electrophoresis (Singh et al.: Bioscience Reports 6:73-79, 1986). By immunofluorescence microscopy, MAb J1-31 stains those cells that are also stained by antiserum to glial fibrillary acidic protein (GFAP), namely astrocytes, retinal Muller cells, and tanycytes in the ependyma (Predy et al.: Bioscience Reports 7:491-502, 1987). In addition, MAb J1-31 stains ciliated ependymal cells that do not express GFAP {Malhotra, SK (1989) J Neurosci Res. 22(1):36-49}.

免疫原

Human cerebral white matter plaque materials from a multiple sclerosis patient.
Epitope: a marker for Low Grade Astrocytoma

应用

Research Sub Category
Neuronal & Glial Markers
Detect Astrocytomas using this Anti-Astrocytomas Antibody, a marker for Low Grade Astrocytoma, clone J1-31 validated for use in WB, IC, IH(P).
Research Category
Neuroscience
Western blot: reducing conditions, recognizes a 30kDa protein {Singh, R et al (1986) Biosci Rep 6(1):73-80.

Immunohistochemistry The antibody works on paraffin embedded tissue sections.

Immunocytochemistry

Optimal working dilutions must be determined by the end user.

联系

Replaces: MAB5314

外形

Ascites fluid. Liquid.

储存及稳定性

Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.

法律信息

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss32160702
NACRESNA.41

产品性质

质量水平100
生物来源mouse
抗体形式ascites fluid
antibody product typeprimary antibodies
克隆J1-31, monoclonal
species reactivitymouse, rat, guinea pig, human
manufacturer/tradenameChemicon®
technique(s)immunocytochemistry: suitable
immunohistochemistry: suitable (paraffin)
western blot: suitable
同位素/亚型IgM
运输dry ice

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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