Anti-ATAD3A antibody produced in rabbit

产品说明

一般描述

ATAD3A and ATAD3B (MIM 612317) are mitochondrial membrane proteins that contribute to the stabilization of large mitochondrial DNA (mtDNA)-protein complexes called nucleoids (He et al., 2007 [PubMed 17210950]).[supplied by OMIM]
ATPase family, AAA domain containing 3A (ATAD3A) is a mitochondrial protein, encoded by the gene mapped to human chromosome 1p36.33. The encoded protein is one of the paralogs of ATAD3 gene family. ATAD3A is ubiquitously expressed.

免疫原

ATAD3A (AAH33109.1, 1 a.a. ~ 586 a.a) full-length human protein.

Sequence
MSWLFGINKGPKGEGAGPPPPLPPAQPGAEGGGDRGLGDRPAPKDKWSNFDPTGLERAAKAARELEHSRYAKDALNLAQMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQAEERRKTLSEETRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRRATVEREMELRHKNEMLRVEAEARARAKAERENADIIREQIRLKAAEHRQTVLESIRTAGTLFGEGFRAFVTDWDKVTATVAGLTLLAVGVYSAKNATLVAGRFIEARLGKPSLVRETSRITVLEALRHPIQVSRRLLSRPQDALEGVVLSPSLEARVRDIAIATRNTKKNRSLYRNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMGREGVTAMHKLFDWANTSRRGLLLFVDEADAFLRKRATEKISEDLRATLNAFLYRTGQHSNKFMLVLASNQPEQFDWAINDRINEMVHFDLPGQEERERLVRMYFDKYVLKPATEGKQRLKLAQFDYGRKCSEVARLTEGMSGREIAQLAVSWQATAYASEDGVLTEAMMDTRVQDAVQQHQQKMCWLKAEGPGRGDEPSPS

生化/生理作用

ATPase family, AAA domain containing 3A (ATAD3A) regulates mitochondrial dynamics and aids in the interaction between mitochondria and the endoplasmic reticulum. In addition, the encoded protein is also involved in mitochondrial development, organization of nucleoid, translation of protein, cell growth and cholesterol metabolism. Elevated expression of ATAD3A serves as a biomarker for radioresistance in glioblastoma multiforme. It is also associated with cancers such as uterine cervical cancer, lung adenocarcinoma and prostate cancer. Mutation in ATAD3A causes delayed development, optic atrophy, axonal neuropathy, hypotonia and hypertrophic cardiomyopathy. Silencing ATAD3A expression promotes autophagy and apoptosis in uterine cervical cancer cells and reduces resistance to anticancer drugs.

外形

Solution in phosphate buffered saline, pH 7.4

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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