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Anti-BCL7A Antibody, clone 15C

品牌
Sigma-Aldrich
货号
MABC523
规格纯度
clone 15C, from mouse
参考价格
4984.03 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-BCL7A Antibody, clone 15C
B-cell CLL/lymphoma 7 protein family member A
产品介绍:

产品说明

一般描述

The protein named B-cell CLL/lymphoma 7 protein family member A or BCL7A and encoded by the human gene named BCL7A is protein that interacts with SWI/SNF components (a nucleosome remodeling complex), implicating that BCL7A’s normal function involves chromatin remodeling. BCL7A was original cloned from a chromosomal translocation in a Burkitt lymphoma cell line and appears to be important in B cell malignancy. Overexpression of BCL7A is associated with germinal center phenotype formation in B cells and BCL7A expression is up regulated in CLL and multiple myeloma but lower in mycosis fungoides and peripheral T cell lymphoma. Recent research indicates that BCL7A was expressed at the pro B and T cell stage and persisted through the pre-B and mature B cell stages. BCL7A expression was maintained in late B cell differentiation but down-regulated in late plasma cells and mature T cells. In haematological malignancies, BCL7A protein was present in the majority of precursor and mature B cell lymphomas with increased expression amongst GC-related lymphomas. Mature T cell malignancies did not express BCL7A.

免疫原

His-tagged recombinant protein corresponding to human BCL7A.

应用

Research Sub Category
Cell Cycle, DNA Replication & Repair
Immunofluorescence Analysis: A 1:10 dilution from a representative lot detected BCL7A in human tonsil tissue (Prof. G. Roncador, CNIO, Madrid).

Immunohistochemistry Analysis: A 1:500 dilution from a representative lot detected BCL7A in human lymph node, spleen, and thymus tissue (Prof. G. Roncador, CNIO, Madrid).

Immunohistochemistry Analysis: A representative lot detected BCL7A in HEK293 cells transfected with BCL7A, and not in HEK293 cells transfected with SPIB protein (Prof. G. Roncador, CNIO, Madrid).
Research Category
Apoptosis & Cancer
Anti-BCL7A Antibody, clone 15C is a highly specific mouse monoclonal antibody, that targets B-cell CLL/lymphoma 7 protein family member A & has been tested in IHC & Immunofluorescence.

质量

Evaluated by Immunohistochemistry in human tonsil and colon tissues.

Immunohistochemistry Analysis: A 1:500 dilution of this antibody detected BCL7A in human tonsil and colon tissues.

目标描述

23 kDa calculated

外形

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Format: Purified
Protein G Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss32160702
NACRESNA.41

产品性质

质量水平100
生物来源mouse
抗体形式purified immunoglobulin
antibody product typeprimary antibodies
克隆15C, monoclonal
species reactivityhuman
technique(s)immunofluorescence: suitable
immunohistochemistry: suitable
同位素/亚型IgG1κ
NCBI登记号NP_001019979
UniProt登记号Q4VC05
运输wet ice
Gene Informationhuman ... BCL7A(605)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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