Anti-beta Arrestin 1 Antibody, clone 3H11.2

产品说明

一般描述

The Arrestin family consists of four members: Arrestin 1 (visual Arrestin), Arrestin 2 (beta Arrestin 1), Arrestin 3 (beta Arrestin 2), and Arrestin 4 (cone Arrestin). While visual and cone Arrestins are found almost exclusively in the retina, beta Arrestins 1 and 2 are ubiquitously expressed. Beta Arrestins appear to act as negative regulators on G protein-coupled receptors, (Lefkowitz, 1998). Interaction with molecules such as clathrin, AP-2 and NSF directs the clathrin-mediated internalization of G-protein-coupled receptors. Interaction with molecules such as Src, Raf, Erk, ASK1 and JNK3 appears to regulate several pathways that result in the activation of MAP kinases, (Lin, 1998; Miller, 2001).

特异性

Other species have not been tested.
Reacts with human beta-arrestin 1.

免疫原

KLH conjugated synthetic peptide corresponding to amino acids 357-372 of human beta arrestin 1.
Epitope: a.a. 357-372

应用

Research Category
Cell Structure
Research Sub Category
Sensory & PNS

G-proteins
Anti-beta Arrestin 1 Antibody, clone 3H11.2 detects level of beta Arrestin 1 & has been published & validated for use in WB & IF.

质量

Evaluated on a representative lot by Western blot in HEK293 cell lysate.

目标描述

~47 kDa

外形

Purified in PBS with 0.05% NaN3.
Format: Purified
Ammonium Sulfate Precipitation

储存及稳定性

Maintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt.

分析说明

Control
HEK293 cell lysate

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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