Anti-BMI1 (C-terminal) antibody produced in rabbit

产品名称：

Anti-BMI1 (C-terminal) antibody produced in rabbit
Anti-Polycomb group RING finger protein 4
Anti-RNF51
Anti-PCGF4
Anti-B lymphoma Mo-MLV insertion region 1 homolog
Anti-Ring finger protein 51

产品介绍：

产品说明

一般描述

Anti-BMI1 (C-terminal) is produced in rabbit using as the immunogen a synthetic peptide corresponding to a sequence at the C-terminal of human BMI1, conjugated to KLH. The human proto-oncogene BMI1 (also known as polycomb complex protein BMI-1, polycomb group RING finger protein 4, and RING finger protein 51) is a member of the mammalian Polycomb group (Pc-G) genes.

应用

Anti-BMI1 (C-terminal) antibody produced in rabbit has been used in:

western blotting
immunoprecipitation
immunofluorescence

生化/生理作用

BMI1 (Proto-Oncogene, Polycomb Ring Finger) plays an important role as epigenetic gene silencers during development. Elevated expression of BMI1 is associated with many cancers such as mantle cell lymphoma, B-cell non-Hodgkin′s lymphoma, myeloid leukemia, non-small cell lung cancer, colorectal cancer, breast cancer and prostate cancer. BMI1 has been shown to be also required for self-renewal of hematopoietic stem cells and neuronal stem cells. BMI1 knockout in mice results in defects in hematopoiesis, skeletal patterning and neurological functions.

外形

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

产品性质

生物来源	rabbit
偶联物	unconjugated
抗体形式	affinity isolated antibody
antibody product type	primary antibodies
克隆	polyclonal
形式	buffered aqueous glycerol solution
分子量	antigen ~37 kDa
species reactivity	human
包装	antibody small pack of 25 μL
浓度	~1.0 mg/mL
technique(s)	immunoprecipitation (IP): 2.5-5 μg using lysates of HEK-293T cells over expressing human BMI1 indirect immunofluorescence: 1-2 μg/mL using paraformaldehyde fixed HEK-293T cells over expressing human BMI1 western blot: 2-4 μg/mL using lysates of HEK-293T cells over expressing human BMI1
UniProt登记号	P35226
运输	dry ice
储存温度	−20℃
Gene Information	human ... BMI1(648)

安全信息

储存分类代码	12 - Non Combustible Liquids
闪点(F)	Not applicable
闪点(C)	Not applicable