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Anti-BMP4 Antibody, clone PA354-16.1.1

品牌
Sigma-Aldrich
货号
MABD411
规格纯度
clone PA354-16.1.1, from mouse
参考价格
5520.38 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-BMP4 Antibody, clone PA354-16.1.1
Bone morphogenetic protein 4, BMP-4, Bone morphogenetic protein 2B, BMP-2B
产品介绍:

产品说明

一般描述

Bone morphogenetic protein 4 (BMP4), also known as Bone morphogenetic protein 4 (BMP-4), Bone morphogenetic protein 2B (BMP-2B), and encoded by the gene name BMP4/ BMP2B/ DVR4, is morphogenetic protein that induces cartilage and bone formation. Similar to other bone morphogenetic proteins, BMP4 has been shown to play an important role in bone and cartilage development, specifically tooth and limb development and fracture repair. It has been shown to be involved in muscle development, bone mineralization, and uteric bud development. BMP4 has also been implicated in Fibrodysplasia Ossificans Progressiva. In human embryonic development, BMP4 is a critical signalling molecule required for the early differentiation of the embryo and establishing of a dorsal-ventral axis. BMP4 is secreted from the dorsal portion of the notochord, and it acts in concert with sonic hedgehog (released from the ventral portion of the notochord) to establish a dorsal-ventral axis for the differentiation of later structures. BMP4 stimulates differentiation of overlying ectodermal tissue. Inhibition of the BMP4 signal (by chordin, noggin, or follistatin) causes the ectoderm to differentiate into the neural plate. If these cells also receive signals from FGF, they will differentiate into the spinal cord; in the absence of FGF the cells become brain tissue.

免疫原

MBP-tagged recombinant protein corresponding to human BMP4.

应用

Research Sub Category
Cell Cycle, DNA Replication & Repair
Research Category
Stem Cell Research
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected BMP4 in human pancreas tissue.
Flow Cytometry Analysis: 1:200 dilution of this antibody from a representative lot detected BMP4 in Caco-2 cells (Data courtesy of Juan Ignacio Imbaud, Protein Alternatives).
This Anti-BMP4 antibody is validated for use in WB, FC, IH for the detection of BMP4.

质量

Evaluated by Western Blotting in human recombinant protein BMP4.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected 0.01 µg human recombinant protein BMP4.

目标描述

47 kDa calculated. The calculated molecular weight is 47 kDa, however BMP4 has been shown as a ~80 and ~90 kDa band in western blots with the use of a MBP tag.

外形

Format: Purified
Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Protein G Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to lot specific datasheet.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss32160702
NACRESNA.75

产品性质

质量水平100
生物来源mouse
抗体形式purified immunoglobulin
antibody product typeprimary antibodies
克隆PA354-16.1.1, monoclonal
species reactivityhuman
technique(s)flow cytometry: suitable
immunohistochemistry: suitable
western blot: suitable
同位素/亚型IgG2aκ
NCBI登记号NP_001193
UniProt登记号P12644
运输wet ice

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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