Anti-BORA antibody produced in rabbit

产品说明

一般描述

BORA (aurora borealis) is a conserved protein in vertebrates. BORA is expressed in nucleus and translocated to cytoplasm upon activation by Cyclin-dependent kinase 2 (Cdc2). In human chromosome, the gene BORA is localized on 13q22.1.

免疫原

Bora antibody was raised against a 15 amino acid peptide from near the carboxy terminus of human Bora.

应用

Anti-BORA antibody produced in rabbit has been used in immunohistochemistry and western blotting studies.

生化/生理作用

Overexpression of Bora in breast, lung and gastric adenocarcinomas leads to enhanced cell proliferation.

特点和优势

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目标描述

Bora (Protein aurora borealis) is a key activator of Aurora Related Protein Kinase A (ARK-1), which is a centrosome-associated serine/threonine kinase that regulates centrosome maturation, bipolar spindle assembly and chromosome segregation during mitosis. Bora is localized to the nucleus until mitosis is initiated, then translocates to the cytoplasm in a Cdc2 dependent manner. Activation of Cdc2 initiates the release of Bora into the cytoplasm where it can bind and activate ARK-1. PLK1 (polo-like kinase-1) interacts with Bora to control the accessibility of its activation loop for phosphorylation and activation by ARK-1. Bora and ARK-1 cooperatively activate PLK1 and control mitotic entry. Bora mutants result in multipolar spindles in mitosis identical to those observed when ARK-1 function is blocked. Thus, the ARK1-Bora-PLK1 regulatory circuit in mammalian cells elucidates a key mechanism in cell cycle regulation. At least three isoforms of Bora are known to exist.

联系

The action of this antibody can be blocked using blocking peptide SBP3500025.

外形

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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