Anti-CA3 antibody produced in rabbit

产品说明

一般描述

Anti-CA3 Antibody detects endogenous levels of total CA3 protein.
Carbonic anhydrase III (CA3) is a member of a multi-gene CA family that encodes carbonic anhydrase isozymes namely Car3 and CAIII. The expression of isozymes has been shown to abundantly increase during muscle aging and is relatively muscle specific. It exhibits a fibre type-specific expression pattern.

免疫原

The antiserum was produced against synthesized peptide derived from human CA3.

Immunogen Range: 141-190

应用

Anti-CA3 antibody produced in rabbit is suitable for indirect ELISA and western blot applications.

生化/生理作用

Carbonic anhydrase III (CA3) may act as a new biomarker of sarcopenia. Higher CA levels indicate an increased demand of CO₂ removal in senescent muscle and the age-related fibre type shifts to slower-contracting muscles during human aging. CA3 is found to be associated with rheumatoid arthritis. It is specifically insufficient in the skeletal muscle of patients suffering from Myasthenia gravis (MG) (an autoimmune disease mainly mediated by antibodies against acetylcholine receptor). CA3 possesses low carbon dioxide hydratase activity, resistance to the CA inhibitor acetazolamide unlike the other members of the CA family.

特点和优势

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外形

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

基本信息

产品性质

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