Anti-CAND1 antibody produced in rabbit

产品说明

一般描述

Cullin-associated and neddylation-dissociated protein 1 (CAND1) is a 120-kDa Huntington, elongation factor 3, PR65/A, TOR (HEAT) repeat-containing protein. It is a centrosomal protein located in the nucleus and cytoplasm. CAND1 gene is located on human chromosome 12q14.

免疫原

Synthetic peptide directed towards the middle region of human CAND1

生化/生理作用

Cullin-associated Nedd8-dissociated protein 1 (CAND1) can modulate cyclin D, c-Jun, and S-phase kinase-associated protein 2 (Skp2). It plays a key role in centriole duplication control. CAND1 binds to cullin 1 (CUL1) and suppresses the activity of Skp1–Cullin–F-box (SCF) ubiquitin ligase. It is required to control cullin-RING ubiquitin (Ub) ligases (CRLs) in eukaryotic cells. It plays an essential role in adipogenesis. CAND1 is a well-known target for the treatment of obesity and several cancer types. CAND1 prevents neddylation of CUL1 by physically blocking access to the neddylation site. It enhances transcription from various types of promoters. CAND1 disrupts interactions between CUL1 and SKP1A and between CUL1 and F-box proteins.

序列

Synthetic peptide located within the following region: AALLTIPEAEKSPLMSEFQSQISSNPELAAIFESIQKDSSSTNLESMDTS

外形

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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