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Anti-CCR5 antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB3501179
规格纯度
affinity isolated antibody
参考价格
4802.96 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-CCR5 antibody produced in rabbit
产品介绍:

产品说明

一般描述

CCR5 Antibody: Human immunodeficiency virus (HIV) and related virus require coreceptors, in addition to CD4, to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b and CCR8 in the chemokine receptor family, and four new human molecules GPR15, STRL33, GPR1 and V28 were recently identified as HIV coreceptors. Among them, CCR5 (CC-CKR-5) is a principal coreceptor for macrophage- and dual-tropic HIV-1 strains fusion and entry of human white blood cells. CCR5 is required for the infection by HIV-1, HIV-2, and SIV. The beta-chemokines RANTES, MIP-alpha and MIP-beta are the ligands for CCR5 and prevent infection by M-tropic HIV-1. CXC5 associates with the surface CD4-gp120 of HIV complex and leads to membrane fusion and virus entry of target cells. The amino-terminal domain and the extracellular loops of CCR5 serve as HIV biding sites. CCR5 messenger RNA is expressed in lymphoid organs and monocytes.

免疫原

CCR5 antibody was raised against a 15 amino acid peptide near the amino terminus of human CCR5.The immunogen is located within the first 50 amino acids of CCR5.

应用

CCR5 antibody can be used for Western blot at 1 μg/mL. CCR5 antibody can also detect CCR5 by immunohistochemistry at 2.5 μg/mL. Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

外形

Supplied in PBS containing 0.02% sodium azide.

产品性质

生物来源rabbit
质量水平100
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式liquid
species reactivityhuman
浓度1 mg/mL
technique(s)immunohistochemistry: suitable
western blot: suitable
同位素/亚型IgG
UniProt登记号P51681
运输wet ice
储存温度−20℃
Gene Informationhuman ... CCR5(1234)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKnwg
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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