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位置:首页 > 品牌 > Sigma-Aldrich > Anti-CFTR Antibody, a.a. 1370-1380, clone M3A7

Anti-CFTR Antibody, a.a. 1370-1380, clone M3A7

品牌
Sigma-Aldrich
货号
MAB3480
规格纯度
clone M3A7, Chemicon®, from mouse
参考价格
6190.47 *本价格含增值税费
促销
服务
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数量
-+
产品名称:
Anti-CFTR Antibody, a.a. 1370-1380, clone M3A7
CFTR
产品介绍:

产品说明

一般描述

CFTR (Cystic Fibrosis Transmembrane Regulator) is an integral membrane protein shown to be involved in the transport of chloride ions. It is found on the surface of the epithelial cells lining the lungs and other organs. CFTR defects are the cause of cystic fibrosis.

Cystic Fibrosis (CF) is a common lethal genetic disease caused by mutations of the gene coding for the cystic fibrosis transmembrane conductance factor, a cAMP regulated chloride channel. Approximately 70% of all CF cases share the deletion of a phenylalanine at position 508 (delta F508) which results in abnormal chloride transport. Since the CF mutation is lethal, most often by lung and liver disease, it raises the question of why this genetic disease remains as common as it is. One possible explanation is that Salmonella typhi has been shown to use CFTR to enter intestinal epithelial cells and that delta F508 heterozygote and homozygote mice showed 86% and 100% reductions in S.typhi intestinal submucosal uptake.

特异性

Recognizes Human cystic fibrosis transmembrane conductance regulator (CFTR). Recognizes an epitope at the C-terminal end of the second nucleotide binding in the region of residues 1370 to 1380.

免疫原

Recombinant protein encoding NBF2 domain of human CFTR
Epitope: a.a. 1370-1380

应用

Western blot: 1μg/mL, do not boil, recognizes 170kDa CTFR protein.

Immunoprecipitation

Immunofluorescence

T84 adenocarcinoma cells are a good positive control

Immunohistochemistry: 1-50μg/mL on acetone fixed frozen sections. Does not work on paraffin embedded tissue.

Optimal working dilutions must be determined by the end user.
Anti-Cystic Fibrosis Transmembrane Conductance Regulator Antibody, a.a. 1370-1380, clone M3A7 detects level of Cystic Fibrosis Transmembrane Conductance Regulator & has been published & validated for use in IC, IP & WB.
Research Category
Neuroscience
Research Sub Category
Ion Channels & Transporters

目标描述

170 kDa

外形

Format: Purified
Protein A purified
Protein A Purified mouse immunoglobulin in 20 mM sodium phosphate, 250 mM NaCl, pH. 7.6, with 0.1% sodium azide as a preservative.

储存及稳定性

Maintain for 1 year at 2–8°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

分析说明

Control
T84 whole cell extract

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

法律信息

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss32160702
NACRESNA.41

产品性质

质量水平100
生物来源mouse
抗体形式purified immunoglobulin
antibody product typeprimary antibodies
克隆M3A7, monoclonal
species reactivityhuman
should not react with mouse, rat, shark
manufacturer/tradenameChemicon®
technique(s)immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
同位素/亚型IgG1
NCBI登记号NM_000492.3
UniProt登记号P13569
运输wet ice

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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