产品说明
一般描述
CHRDL2 (Chordin-like 2) is a novel chordin-related gene belonging to the chordin family of proteins. It encodes a putative extracellular matrix protein consistsing of a signal peptide and three cysteine-rich (CR) domains. In humans, it expressed in several normal adult tissues predominantly in liver, heart, prostate, testis, and ovary.
免疫原
CHRDL2 (AAI53101.1, 1 a.a. ~ 451 a.a) full-length human protein.
Sequence
MVPEVRVLSSLLGLALLWFPLDSHARARPDMFCLFHGKRYSPGESWHPYLEPQGLMYCLRCTCSEGAHVSCYRLHCPPVHCPQPVTEPQQCCPKCVEPHTPSGLRAPPKSCQHNGTMYQHGEIFSAHELFPSRLPNQCVLCSCTEGQIYCGLTTCPEPGCPAPLPLPDSCCQACKDEASEQSDEEDSVQSLHGVRHPQDPCSSDAGRKRGPGTPAPTGLSAPLSFIPRHFRPKGAGSTTVKIVLKEKHKKACVHGGKTYSHGEVWHPAFRAFGPLPCILCTCEDGRQDCQRVTCPTEYPCRHPEKVAGKCCKICPEDKADPGHSEISSTRCPKAPGRVLVHTSVSPSPDNLRRFALEHEASDLVEIYLWKLVKDEETEAQRGEVPGPRPHSQNLPLDSDQESQEARLPERGTALPTARWPPRRSLERLPSPDPGAEGHGQSRQSDQDITKT
生化/生理作用
CHRDL2 (Chordin-like 2) may play a role in the cartilage regeneration, myoblast and osteoblast differentiation. It has been reported that CHRDL2 may negatively regulate the cartilage formation/regeneration from immature mesenchymal cells. CHRDL2 restricts BMPs activity by blocking their interaction with its type I BMP receptor ectodomain. Overexpressed expression of CHRDL2 has been reported in several cancerous tissues such as breast, lung and colon cancers.
外形
Solution in phosphate buffered saline, pH 7.4
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 偶联物 | unconjugated |
| 抗体形式 | purified immunoglobulin |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | antigen 49.61 kDa |
| species reactivity | human |
| technique(s) | western blot: 1 μg/mL |
| NCBI登记号 | BC153100.1 |
| UniProt登记号 | Q6WN34 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | human ... CHRDL2(25884) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
