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Anti-Claudin-1 antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB4200462
规格纯度
~1.0 mg/mL, affinity isolated antibody
参考价格
5045.46 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-Claudin-1 antibody produced in rabbit
Anti-CLD1
Anti-ILVASC
Anti-CLDN1
Anti-SEMP1
产品介绍:

产品说明

一般描述

Anti-Claudin-1 is produced in rabbit using as immunogen a synthetic peptide corresponding to a sequence located at the C-terminal region of human claudin-1, conjugated to KLH. Claudin-1 (also known as CLDN1, senescence-associated epithelial membrane protein (SEMP1) and ILVASC) is a 22 kDa protein. It is expressed at high levels in kidney and liver and at lower levels in spleen, heart, brain, lung and testis. Claudins are located in both epithelial and endothelial cells in tissues. Claudins consist of four transmembrane domains and two extracellular loops, required to form tight junction strands. CLDN1 gene is located on human chromosome 3q28.

免疫原

synthetic peptide corresponding to a sequence located at the C-terminal region of human claudin-1, conjugated to KLH. The corresponding sequence is identical in rat claudin-1 and highly conserved (single amino acid substitution) in mouse claudin-1.

应用

Anti-Claudin-1 antibody produced in rabbit has been used in immunohistochemistry and immunoblotting,

生化/生理作用

Claudin-1 is frequently up-regulated in colorectal carcinomas (CRCs), resulting in tumor differentiation and progression. Defects in the gene encoding claudin-1 are the cause of an autosomal recessive syndrome named ichthyosis-sclerosing cholangitis neonatal (NISCH). It participates in the barrier formation of tight junction. It modulates the tight junctions in human airway epithelium. CLDN1 acts as a receptor for the hepatitis C virus entry.

外形

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.41

产品性质

生物来源rabbit
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
分子量antigen ~23 kDa
species reactivityrat, human
浓度~1.0 mg/mL
technique(s)immunohistochemistry: 20 μg/mL using formalin-fixed, paraffin-embedded rat kidney.
western blot: 1.5-3.0 μg/mL using extracts of rat kidney (S1 fraction).
UniProt登记号O95832
运输dry ice
储存温度−20℃
Gene Informationhuman ... CLDN1(9076)
rat ... Cldn1(65129)

安全信息

储存分类代码12 - Non Combustible Liquids
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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