产品说明
一般描述
Anti-Claudin 11 Antibody detects endogenous levels of total Claudin 11 protein.
Claudin-11 (CLDN11) gene codes for an integral membrane protein of the paracellular tight junction (TJ). CLDN11 protein belongs to the claudin family. It is a vital constituent of the central nervous system myelin. Expression of CLDN11 is mainly seen in the brain and testes. CLDN11 gene is located on human chromosome 3q26.2. Anti-Claudin 11 antibody detects endogenous levels of total Claudin 11 protein.
免疫原
The antiserum was produced against synthesized peptide derived from human Claudin 11.
Immunogen Range: 158-207
生化/生理作用
Claudin-11 (CLDN11) gene is a tumor suppressor. CLDN11 protein controls bone homeostasis. Knockdown of the CLDN11 gene in cancer cells can affect motility and invasiveness. It might be involved in preventing the development of cancer. CLDN11 gene silencing by DNA hypermethylation stimulates the progression of nasopharyngeal carcinoma. In addition, hypermethylation and silencing of the CLDN11 gene are observed in oral leukoplakias, gastric cancer, bladder cancer, and malignant melanoma.
特点和优势
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外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | antigen 21 kDa |
| species reactivity | mouse, rat, human |
| 浓度 | ~1 mg/mL |
| technique(s) | ELISA: 1:1000 western blot: 1:500-1:1000 |
| NCBI登记号 | O75508 |
| UniProt登记号 | O75508 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... CLDN11(5010) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | nwg |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
