产品说明
一般描述
CNOT3 is a subunit of the CCR4-NOT transcription complex. This subunit can bind to the PRPF31 promoter and mediate transcriptional repression. It acts as a modifier gene and controls the effects of PRPF31 mutations in retinitis pigmentosa. CNOT3 mutations have also been implicated in T-cell acute lymphoblastic leukemia (T-ALL).
Rabbit Anti-CNOT3 antibody recognizes bovine, human, mouse, rat, zebrafish, canine, and rabbit CNOT3.
免疫原
Synthetic peptide directed towards the N terminal region of human CNOT3
应用
Rabbit Anti-CNOT3 antibody can be used for western blot applications at a concentration of 0.5 μg/ml.
生化/生理作用
CNOT3 is a protein component of CCR4-NOT protein complex. Yeast CCR$-NOT is a global regulator of RNA polymerase II transcription. It is comprised of yeast NOT1 to NOT5, yeast CCR4 and additional proteins like yeast CAF1.
序列
Synthetic peptide located within the following region: QFESEVESLSVQTRKKKGDKDKQDRIEGLKRHIEKHRYHVRMLETILRML
外形
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | 82 kDa |
| species reactivity | horse, rat, dog, bovine, guinea pig, mouse, human, rabbit |
| 浓度 | 0.5 mg - 1 mg/mL |
| technique(s) | western blot: suitable |
| NCBI登记号 | NP_055331 |
| UniProt登记号 | O75175 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... CNOT3(4849) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
