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Anti-Coronin-1A (N-terminal) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB4200078
规格纯度
~1.5 mg/mL, affinity isolated antibody
参考价格
5045.46 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-Coronin-1A (N-terminal) antibody produced in rabbit
Anti-CLABP
Anti-TACO (tryptophane aspartate-containing coat protein)
Anti-CLIPINA (coronin-like protein A)
Anti-HCORO1
Anti-CORO1A
Anti-p57
产品介绍:

产品说明

一般描述

Coronin 1A (Coronin-1A) is encoded by the gene mapped to human chromosome 16p11.2. The encoded 57kDa protein, belongs to the coronin family and is mainly expressed in hematopoietic cells. Coronin family of proteins are characterized with a highly conserved N-terminal extension (NE), five canonical WD40 repeats, a C-terminal conserved extension (CE), followed by a unique region (U), and ends with a C-terminal coiled-coil (CC) domain.

应用

Anti-Coronin-1A (N-terminal) antibody produced in rabbit has been used in immunoblotting.

生化/生理作用

Coronin 1A (Coronin-1A) plays a vital role in F-actin stabilization in vitro. It is also involved in phagocytosis by neutrophils and macrophages and in T-cell receptor (TCR)-mediated activation of T lymphocytes. Additionally, it is also implicated in the regulation of activate actin-related protein-2/3 (Arp2/3)-dependent processes. Mutation in the gene has been observed in T cell-deficient, B cell- and natural killer (NK) cell-sufficient (T?B+NK+) severe combined immunodeficiency (SCID) patients.
Coronin-1A also plays a vital role in regulation of leukocyte specific signaling. In T-lymphocytes, coronin-1A facilitates the association of cytoskeleton dynamics to TCRαβ induced cell signaling, chemokine-mediated cell migration and homeostasis. Loss of coronin-1A gene expression in murine T cells leads to reduced ability to respond to chemotactic gradient and decrease in peripheral T cells due to apoptosis.

外形

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.41

产品性质

生物来源rabbit
质量水平200
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
分子量antigen ~57 kDa
species reactivitymouse, human, rat
浓度~1.5 mg/mL
technique(s)western blot: 1.5-3.0 μg/mL using Jurkat cell lysates, or lysates of mouse brain (S1 fraction) or rat spleen (S1 fraction)
UniProt登记号P31146
运输dry ice
储存温度−20℃
Gene Informationhuman ... CORO1A(11151)
mouse ... Coro1a(12721)
rat ... Coro1a(155151)

安全信息

储存分类代码12 - Non Combustible Liquids
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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