Anti-CTSC antibody produced in rabbit

产品说明

一般描述

The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in immune/inflammatory cells. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor, and a residual portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride ions for activity and can degrade glucagon. Defects in the encoded protein have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis. Multiple transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq)
Cathepsin C (CTSC) is a cysteine exopeptidase that is part of the peptidase C1 family. It consists of a polypeptide chain which folds into a propeptide, an exclusion domain and two papain-like domains. The CTSC gene is localized on human chromosome 11q14.2 and has seven exons.

免疫原

CTSC (NP_001805.1, 1 a.a. ~ 463 a.a) full-length human protein.

Sequence
MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNTAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL

生化/生理作用

Cathepsin C (CTSC) activates proinflammatory serine proteases in neutrophils, natural killer cells, mast cells and cytotoxic T lymphocytes. It cleaves dipeptides from the free amino terminals of peptides and proteins. CTSC has a role in the cleavage of hormones like glucagon, gastrin and angiotensin II. Mutations in the gene encoding CTSC have been associated with Papillon-Lefevre syndrome.

外形

Solution in phosphate buffered saline, pH 7.4

基本信息

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