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Anti-Cullin 3 antibody ,Mouse monoclonal

品牌
Sigma-Aldrich
货号
SAB4200180
规格纯度
clone CUL3-9, purified from hybridoma cell culture
参考价格
6105.86 *本价格含增值税费
促销
服务
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  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-Cullin 3 antibody ,Mouse monoclonal
Anti-CUL3
产品介绍:

产品说明

一般描述

Cullin 3 (CUL3) is a member of cullin protein family and is encoded by the gene mapped to human chromosome 2q36.2. The encoded protein is a core component of cullin/RING E3 ubiquitin ligase (CRL) and is ubiquitously expressed. The protein is characterized with a cullin homology domain.
Monoclonal Anti-Cullin 3 (mouse IgG1 isotype) is derived from the hybridoma CUL3-9 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide of human Cullin 3.

应用

Monoclonal Anti-Cullin 3 antibody produced in mouse has been used in western blotting and immunoprecipitation.

生化/生理作用

Cullin 3 (CUL3) acts as a scaffold protein and facilitates the organization of a large number of ubiquitin ligase complexes. It plays a vital role in the regulation of electrolyte homeostasis and blood pressure. The encoded protein acts as a key factor in protein ubiquitination and is also implicated in early embryonic development. One important role of CUL3 is to promote invasion and migration of trophoblast cells. Mutation in the gene leads to onset of pre-eclampsia and pseudohypoaldosteronism type II.

外形

0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号MFCD03454920
NACRESNA.41

产品性质

生物来源mouse
偶联物unconjugated
抗体形式purified from hybridoma cell culture
antibody product typeprimary antibodies
克隆CUL3-9, monoclonal
形式buffered aqueous solution
分子量antigen 80 kDa
species reactivitymouse, rat, human
浓度~1.0 mg/mL
technique(s)immunoprecipitation (IP): suitable
western blot: 0.5-1.0 μg/mL using whole extracts of human Jurkat cells or mouse brain.
同位素/亚型IgG1
UniProt登记号Q13618
运输dry ice
储存温度−20℃
Gene Informationhuman ... CUL3(8452)
mouse ... Cul3(26554)
rat ... Cul3(301555)

安全信息

储存分类代码12 - Non Combustible Liquids
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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