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Anti-CYBB antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB4200118
规格纯度
~1.5 mg/mL, affinity isolated antibody
参考价格
5705.99 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-CYBB antibody produced in rabbit
Anti-CGD
Anti-GP91-1
Anti-NOX2
Anti-Cytochrome b-245, β polypeptide (chronic granulomatous disease)
Anti-GP91-PHOX
产品介绍:

产品说明

一般描述

CYBB (cytochrome b-245), belongs to the family of NADPH oxidases, that catalyze the generation of the superoxide ion. It is a six-transmembrane glycoprotein, that binds heme, flavin and NADPH. CYBB associates with membrane-bound p22phox to assemble the heavy subunit of flavocytochrome b558, the catalytic component of phagocyte NADPH oxidase. It also associates with four cytosolic components p47phox, p67phox, p40phox and Rac2 required for NADPH oxidase activity. Homologs of the NOX protein family include the catalytic subunits NOX1, NOX3-5, Duox1 and Duox2. NOX2/gp91phox is expressed in neutrophils and phagocytes.

应用

Anti-CYBB antibody produced in rabbit has been used in immunoblotting and western blotting.

生化/生理作用

CYBB (also known as cytochrome b-245) promotes neurotoxic activation of microglia, that play a central role during neuroinflammatory states and in amyotrophic lateral sclerosis (ALS). NOX1, NOX3-5, Duox1 and Duox2 plays important roles in redox-dependent cell signaling, inflammation and in neurodegenerative diseases. In ALS mice, deletion of either NOX1 or NOX2 gene has significantly slowed disease progression and improved survival.

外形

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号MFCD02686174
NACRESNA.41

产品性质

生物来源rabbit
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
分子量antigen ~95 kDa
species reactivityhuman
包装antibody small pack of 25 μL
浓度~1.5 mg/mL
technique(s)western blot: 1.5-3.0 μg/mL using RAW264 cell extracts
UniProt登记号P04839
运输dry ice
储存温度−20℃
Gene Informationhuman ... CYBB(1536)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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