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Anti-CYP17A1 (center) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB1300941
规格纯度
saturated ammonium sulfate (SAS) precipitated, buffered aqueous solution
参考价格
4618.16 *本价格含增值税费
促销
服务
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数量
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产品名称:
Anti-CYP17A1 (center) antibody produced in rabbit
Anti-P450c17
Anti-Steroid 17-α-hydroxylase/17,20 lyase
Anti-CYPXVII
Anti-P450-C17
Anti-Steroid 17-α-monooxygenase
产品介绍:

产品说明

一般描述

Cytochrome P450 family 17 subfamily A member 1 (CYP17A1) is a member of the cytochrome P450 superfamily of enzymes. It is encoded by the gene mapped to human chromosome 10q24.32. This protein localizes to the endoplasmic reticulum.

免疫原

CYP17A1 (NP_000093, 363-398)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the Center region of human CYP17A1.

应用

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

生化/生理作用

Cytochrome P450 family 17 subfamily A member 1 (CYP17A1) catalyzes 17Α-hydroxylation of steroid substrates and cleavage and oxidation of their side-chains. It has both 17Α-hydroxylase and 17, 20-lyase activities. The protein acts as a key enzyme in the synthesis of cortisol, testosterone and oestrogen. Mutations in CYP17A1 gene are associated with mineralocorticoid excess syndromes, glucocorticoid and sex hormone deficiencies. In addition, it also increases the risk of susceptibility to prostate cancer, benign prostatic hypertrophy and occasional congenital adrenal hyperplasia (CAH). Abiraterone inhibits steroidogenic activity of CYP17A1 and retards tumor growth in castration-resistant prostate cancer (CRPC) patients.

外形

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.41

产品性质

生物来源rabbit
质量水平100
偶联物unconjugated
抗体形式saturated ammonium sulfate (SAS) precipitated
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
species reactivityhuman
technique(s)indirect ELISA: 1:1000
western blot: 1:100-1:500
NCBI登记号NP_000093
UniProt登记号P05093
运输dry ice
储存温度−20℃
Gene Informationhuman ... CYP17A1(1586)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKnwg
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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