产品说明
一般描述
The Dcr-1 gene encodes a bidentate ribonuclease that is homologous to E. coli RNAse III.
DCR-1 (dicer 1, ribonuclease III) is an RNase ΙΙΙ endoribonuclease. It is located on human chromosome 14q32.
免疫原
DCR (NP_498761, 1008-1042)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the central region of C. elegans Dcr-1.
生化/生理作用
Dcr-1 is required both for RNA interference and for the synthesis of small developmental RNAs. Dcr-1 interacts in vivo with RDE-4, a double-stranded RNA (dsRNA) binding protein required for RNAi that interacts with trigger dsRNAs and may function to deliver dsRNAs to Dcr-1 for endonucleolytic processing.
DCR-1 (dicer 1, ribonuclease III) has the ability to cleave dsRNA into smaller fragments that mediate RNAi. It plays an important role in miRNA processing and participates in innate immunity. DCR-1 is essential for the production of endo-siRNAs implicated in gene silencing and epigenetic modulation.
外形
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| species reactivity | Caenorhabditis elegans |
| technique(s) | indirect ELISA: 1:1000 |
| NCBI登记号 | NP_498761 |
| UniProt登记号 | P34529 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | nwg |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
