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Anti-DNA polymerase subunit gamma-1 Antibody/POLG

品牌
Sigma-Aldrich
货号
ABC462
规格纯度
1.0 mg/mL, from rabbit
参考价格
6022.61 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-DNA polymerase subunit gamma-1 Antibody/POLG
DNA polymerase subunit gamma-1, DNA polymerase subunit gamma-1, PolG-alpha
产品介绍:

产品说明

一般描述

POLG is a mitochondrial protein that plays a major role in mitochondrial DNA replication and only for mitochondrial DNA. POLG is the catalytic subunit of a multiple protein complex that makes up the holo-enzyme that is the mitochondrial specific DNA polymerase gamma. POLG makes the alpha subunit of the complex. A number of diseases are associated with mutations that affect the function of POLG and the mitochondria including Leigh syndrome, various neurodegeneration diseases such as Parkinson’s and Alzheimer′s, as well as various skeletal muscle and ophthalmoplegia disorders and even male infertility. The polymerase that POLG ultimately comprises is Polymerase gamma (Pol γ) and is the only DNA polymerase that is active in mitochondria and that can replicate mtDNA.

免疫原

KLH-conjugated linear peptide corresponding to human DNA polymerase subunit gamma-1/POLG near the N-terminus.

应用

This Anti-DNA polymerase subunit gamma-1 Antibody/POLG is validated for use in Immunohistochemistry and Immunoprecipitation for the detection of DNA polymerase subunit gamma-1/POLG.
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected DNA polymerase subunit gamma-1/POLG in human cerebellum, human cerebral cortex, human tonsil and human thalamus tissue.
Immunoprecipitation Analysis: 10 µg from a representative lot immunoprecipitated DNA polymerase subunit gamma-1/POLG in 0.5 mg of HeLa cell lysate.

质量

Evaluated by Immunohistochemistry in human tonsil tissue.

Immunohistochemistry Analysis: A 1:50 dilution of this antibody detected DNA polymerase subunit gamma-1/POLG in human tonsil tissue.

目标描述

~140 kDa observed. Uncharacterized band(s) may appear in some lysates.

联系

Replaces: MABN1088

外形

Affinity purified

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss32160702
NACRESNA.41

产品性质

生物来源rabbit
质量水平100
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
纯化方式affinity chromatography
species reactivityhuman
浓度1.0 mg/mL
technique(s)immunohistochemistry: suitable
immunoprecipitation (IP): suitable
NCBI登记号NP_001119603
UniProt登记号P54098
运输wet ice
Gene Informationhuman ... POLG(5428)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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