Anti-EndoG antibody produced in rabbit

产品名称：

产品介绍：

产品说明

一般描述

ENDOG (Endonuclease G) is a 28kDa mitochondria-localized protein mapped to human chromosome 9q34.1. However, in presence of certain conditions it can translocate to the nucleus through the BNIP3 (Bcl-2/adenovirus E1B 19kDa protein-interacting protein 3) cell death pathway.

免疫原

EndoG antibody was raised with a synthetic peptide corresponding to 15 amino acids near the amino terminus of human EndoG.

应用

Anti-EndoG antibody produced in rabbit is suitable for immunohistochemistry, indirect ELISA and western blot analysis.

生化/生理作用

ENDOG (Endonuclease G) is a mitochondrial apoptotic DNase involved in the BNIP3 (Bcl-2/adenovirus E1B 19kDa protein-interacting protein 3) cell death pathway. During mitochondrial release and nuclear translocation of EndoG, BNIP3 interacts with the voltage-dependent anion channel (VDAC) to facilitate the process in the nucleus, it cleaves chromatin apoptotic DNA without the need of caspase activity. ENDOG causes DNA fragmentation during and after apoptosis. It is linked with cardiac hypertrophy and Parkinson′s disease.

特点和优势

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联系

The action of this antibody can be blocked using blocking peptide SBP3500213.

外形

Supplied in PBS with 0.02% sodium azide.

基本信息

MDL编号	MFCD04040310
NACRES	NA.41

产品性质

生物来源	rabbit
质量水平	100
偶联物	unconjugated
抗体形式	affinity isolated antibody
antibody product type	primary antibodies
克隆	polyclonal
形式	buffered aqueous solution
分子量	predicted mol wt 35 kDa
species reactivity	rat, human, mouse
technique(s)	immunohistochemistry: suitable indirect ELISA: suitable western blot: suitable
NCBI登记号	NP_004426
UniProt登记号	Q14249
运输	dry ice
储存温度	−20℃
Gene Information	human ... ENDOG(2021)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable