Anti-Endophilin-A1 Antibody

产品说明

一般描述

A member of the Endophilin family, Endophilin A1 is a protein containing SH3 domains, and has been implicated in the trafficking of clathrin-mediated synaptic vesicle endocytosis within the membrane. It was originally characterized as a presynaptically enriched protein that binds to endocytic proteins polyphosphoinositide synaptojanin and dynamin. Endophilin A1 has been implicated in endocytic vesicle budding when its function in cell-free systems and in living synapses has been disturbed. Along with the SH3 domain, Endophilin A1 contains a BAR domain in the N-terminal region, that has been found to induce and bind membrane curvature. This protein’s expression is localized to the brain, most specifically in the frontal cortex. Markedly high expression is observed in fetal cerebellum.

特异性

The antibody recognizes Endophilin-A1.
Human (94% sequence homology).

免疫原

KLH-conjugated linear peptide corresponding to mouse Endophilin-A1.

应用

Western Blot Analysis: 1:500 dilution from a previous lot detected Endophilin-A1 in 10 µg of rat brain and mouse brain membrane tissue lysates.
This Anti-Endophilin-A1 Antibody is validated for use in WB for the detection of Endophilin-A1.

质量

Evaluated by Western Blot in mouse brain tissue lysate.

Western Blot Analysis: 1:500 dilution of this antibody detected Endophilin-A1 in 10 µg of mouse brain tissue lysate.

目标描述

~ 42 kDa

外形

Affinity purified

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

产品性质

安全信息