产品说明
一般描述
Fibroblast growth factor 23 (FGF-23) is also called Phosphatonin and Tumor-derived hypophosphatemia-inducing factor. FGF-23 belongs to the heparin-binding growth factors family and has several important functions including: regulation of phosphate homeostasis, inhibition of renal tubular phosphate transport, upregulation of EGR1 expression, regulation of vitamin-D metabolism, and negative regulation of osteoblast differentiation and matrix mineralization. FGF-23 is expressed in osteogenic cells, adult trabecular bone, osteocytes and flattened bone-lining cells (inactive osteoblasts). Defects in FGF23 can lead to autosomal dominant hypophosphataemic rickets (ADHR) and hyperphosphatemic familial tumoral calcinosis (HFTC).
免疫原
Corresponding to human FGF23.
应用
Flow Cytometry Analysis: 2 µg from a representative lot detected FGF23 in Jurkat and human PMBC cells.
Anti-FGF23 Antibody, clone 278-2 is a mouse monoclonal antibody & validated for use in western blotting.
Research Category
Signaling
Research Sub Category
Developmental Signaling
质量
Evaluated by Western Blotting in human salivary gland tissue lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected FGF23 in 10 µg of human salivary gland tissue lysate.
目标描述
~25 kDa observed
外形
Purified mouse monoclonal IgG1κ in buffer containing PBS with 0.05% sodium azide.
Format: Purified
Protein A purified
储存及稳定性
Stable for 1 year at 2-8°C from date of receipt.
分析说明
Control
Human salivary gland tissue lysate
其他说明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
eCl@ss | 32160702 |
NACRES | NA.41 |
产品性质
质量水平 | 100 |
生物来源 | mouse |
抗体形式 | purified immunoglobulin |
antibody product type | primary antibodies |
克隆 | 278-2, monoclonal |
species reactivity | human |
technique(s) | flow cytometry: suitable western blot: suitable |
同位素/亚型 | IgG1κ |
NCBI登记号 | NP_065689 |
UniProt登记号 | Q9GZV9 |
运输 | wet ice |
Gene Information | human ... FGF23(8074) |
安全信息
储存分类代码 | 12 - Non Combustible Liquids |
WGK | WGK 2 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |
Sigma-Aldrich