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Anti-Gapex-5 antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB4200098
规格纯度
~1.0 mg/mL, affinity isolated antibody
参考价格
4618.16 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-Gapex-5 antibody produced in rabbit
Anti-GAPVD1
Anti-GTPase-activating protein and VPS9 domains 1
Anti-RAB5 exchange factor
Anti-RAP6 (rab5-activating protein 6)
产品介绍:

产品说明

一般描述

GTPase-activating protein and VPS9 domain-containing protein 1 (GAPVD1) also called Rab5-activating protein 6 (RAP6) or Gapex-5 gene is mapped to the human chromosome 9q33.3. It has a carboxy-terminal Vps9-like domain and an amino-terminal Ras GTPase-accelerating proteins (GAP)-like domain. GAPVD1 is present in the plasma membrane and endosomes.

特异性

Anti-Gapex-5 recognizes human Gapex-5.

应用

Anti-Gapex-5 antibody produced in rabbit may be used in immunoblotting and immunoprecipitation.

生化/生理作用

Rab5-activating protein 6 (RAP6) or Gapex-5 is an evolutionary conserved protein and its C-terminal Vps9 domain is responsible for the interaction with guanosine diphosphate GDP bound Rab5 and an N-terminal Ras GTPase-accelerating proteins (GAP) domain. Gapex-5 has guanine nucleotide exchange factor (GEF) activity specific for Rab5 and GAP activity specific for Ras. It is involved in multiple processes including receptor-mediated endocytosis, insulin receptor internalization and glucose transporter type 4 (Glut4) trafficking in adipocytes. RAP6 is also essential for epidermal growth factor receptor (EGFR) trafficking and degradation and phagosome maturation.

外形

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

储存及稳定性

Store at –20 ℃. For continuous use, the product may be stored at 2–8 ℃ for up to one month. For extended storage, freeze in working aliquots at –20 ℃. Storage in “frost-free” freezers is also not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.41

产品性质

生物来源rabbit
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
分子量antigen ~180 kDa
species reactivityhuman
包装antibody small pack of 25 μL
浓度~1.0 mg/mL
technique(s)immunoprecipitation (IP): 5-10 μg using lysates of human HEK-293T cells
western blot: 1-2 μg/mL using whole extracts of human HeLa cells
UniProt登记号Q14C86
运输dry ice
储存温度−20℃
Gene Informationhuman ... GAPVD1(26130)
mouse ... Gapvd1(66691)

安全信息

储存分类代码12 - Non Combustible Liquids
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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