Anti-GGA3 antibody produced in rabbit

产品说明

一般描述

The gene GGA3 (golgi-associated, γ adaptin ear containing, ARF binding proteins) is mapped to human chromosome 17q25.1. The protein contains a GAT (GGA and Tom1) domain and the VHS (Vps27, Hrs, STAM) domain.

免疫原

ADP-ribosylation factor-binding protein GGA3 recombinant protein epitope signature tag (PrEST)

应用

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.

生化/生理作用

GGAs (golgi-associated, γ adaptin ear containing, ARF binding proteins) are adaptor-related proteins, which interact with ADP-ribosylation factors (ARFs). They are present in the trans-Golgi network (TGN) and form connection between clathrin and membrane-bound ARF-GTP (guanosine triphosphate). GGAs play a crucial role in trafficking between the TGN and endosomes. GGA3 also binds to the subunits of the ubiquitin-dependent sorting machinery. It controls trafficking and degradation of BACE1 (β-site AβPP-cleaving enzyme). BACE1 is important for the generation of amyloid-β in Alzheimer′s disease.

特点和优势

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

联系

Corresponding Antigen APREST75610.

外形

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

法律信息

Prestige Antibodies is a registered trademark of sigma-aldrich Co. LLC

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