Anti-Glucagon receptor Antibody

产品说明

一般描述

Glucagon receptor or GL-R (UniProt P47871) is encoded by the GCGR (also known as GGR) gene (Gene ID 2642) in human. Glucagon is a 29-amino acid peptide that stimulates glycogenolysis and gluconeogenesis in the liver to increase blood glucose. The receptor for glucagon is a class 2 (or class B) G protein-coupled receptor (GPCR) that signals through Gs to stimulate cAMP production. Mice lacking the glucagon receptor have mild hypoglycemia after fasting and exhibit hyperplasia of pancreatic alpha-cells. Because of its role in promoting hyperglycemia, the glucagon receptor presents a potential target for treatment of diabetes.

免疫原

KLH-conjugated linear peptide corresponding to the cytoplasmic domain of human Glucagon receptor.
Epitope: Fourth cytoplasmic domain

应用

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Glucagon receptor in human pancreas.
This Anti-Glucagon receptor Antibody is validated for use in Western Blotting, Immunohistochemistry (Paraffin) for the detection of Glucagon receptor.

质量

Evaluated by Western Blotting in human liver tissue lysate.

Western Blotting Analysis: 0.2 µg/mL of this antibody detected Glucagon receptor in 10 µg of human liver tissue lysate.

目标描述

~59 kDa observed. Target band appears larger than the calculated molecular weight of 54.0 kDa (Preform) and 51.3 kDa (mature) due to glycosylation. Lower molecular weight degradation band(s) can also be seen (Iwanij, V., et al. (1990). J. Biol Chem. 265(34):21302-21308).

外形

Affinity purified

其他说明

Concentration: Please refer to lot specific datasheet.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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