Anti-Glutaredoxin-1 antibody produced in rabbit

产品说明

一般描述

Glutaredoxin-1 (Grx1) is encoded by the gene mapped to human chromosome 5q15. The encoded protein is a sulfhydryl disulfide oxidoreductase enzyme with a molecular mass of 12kDa. Grx1 belongs to the oxidoreductase family. Grx is expressed in various types of mammalian cells including human placenta and erythrocytes.
Anti-Glutaredoxin-1 is produced in rabbit using as immunogen a human glutaredoxin-1 recombinant protein (G5298), conjugated to KLH. GRX1 is found in the cytosol and supplies ribonucleotide reductase with electrons.

免疫原

human glutaredoxin-1 recombinant protein conjugated to KLH

应用

Anti-Glutaredoxin-1 antibody produced in rabbit has been used in immunoblotting.

生化/生理作用

Glutaredoxin (Grx) catalyzes glutathione (GSH)-dependent disulfide reductions when coupled to GSH, NADPH and glucocorticoid receptor (GR). Grx1 is implicated in various cellular processes, such as anti-oxidation, anti-apoptosis and regulation of cell differentiation. Additionally, the encoded protein also protects the retinal pigment epithelial (RPE) cells from H₂O₂-induced apoptosis by inhibiting protein kinase B (AKT) glutathionylation. Thus, Grx1 can be used as a potential therapeutic target for retinal degenerative diseases.
GRX1 is involved in general disulfide-dithiol exchanges, dehydroascorbate reduction and regulation of transcription factors.

外形

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide as a preservative

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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