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Anti-Glyoxalase I antibody, Rat monoclonal

品牌
Sigma-Aldrich
货号
SAB4200193
规格纯度
clone Clone 6F10, purified from hybridoma cell culture
参考价格
5045.46 *本价格含增值税费
促销
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数量
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产品名称:
Anti-Glyoxalase I antibody, Rat monoclonal
Monoclonal Anti-Glyoxalase I antibody produced in rat
产品介绍:

产品说明

一般描述

Monoclonal Anti-Glyoxalase I (rat IgG2b isotype) is derived from the hybridoma 6F10 produced by the fusion of mouse myeloma cells and splenocytes from rat immunized with a mouse Glyoxalase I fusion protein. The glyoxalase system, which consists of glyoxalase I (GLO1), glyoxalase II, and a catalytic amount of reduced glutathione (GSH), is important part of cellular metabolism. GLO1 appears to be ubiquitously expressed in all mammalian cells, suggesting its biological importance.

免疫原

mouse Glyoxalase I fusion protein

应用

Monoclonal Anti-Glyoxalase I antibody produced in rat has been used in immunoblotting. and immunocytochemistry.

生化/生理作用

The glyoxalase system plays a major role to detoxify α-ketoaldehydes, especially methylglyoxal (MG), that are endogenously formed as a by-product of the triosephosphate isomerase reaction during glycolysis. A member of this system, GLO1 catalyzes the isomerization of a hemithioacetal, comprised of a nonenzymatic adduct of MG and glutathione (GSH), to the corresponding α-d-hydroxyacid thioester and S-D-lactoylglutathione. Studies have suggested that GLO1 may be important for brain function since, GLO1 in the brain is involved in Alzheimer′s disease, autism, anxiety and the regulation of theta oscillations during sleep.

外形

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.41

产品性质

生物来源rat
偶联物unconjugated
抗体形式purified from hybridoma cell culture
antibody product typeprimary antibodies
克隆Clone 6F10, monoclonal
形式buffered aqueous solution
分子量 ~21 kDa
species reactivityhuman, canine, mouse, rat, monkey
包装antibody small pack of 25 μL
浓度~1.0 mg/mL
technique(s)immunocytochemistry: suitable
western blot: 0.12-0.25 μg/mL using A549, HeLa, SH-SY5Y, COS7 or MDCK cell extracts
同位素/亚型IgG2b
UniProt登记号Q04760
运输dry ice
储存温度−20℃
Gene Informationhuman ... GLO1(2739)
mouse ... Glo1(109801)
rat ... Glo1(294320)

安全信息

储存分类代码12 - Non Combustible Liquids
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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