产品说明
一般描述
GPC4 (glypican-4) gene is mapped to human chromosome Xq26.2. The encoded protein is a heparan sulfate proteoglycan and localizes to membrane microdomains.
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The GPC4 gene is adjacent to the 3′ end of GPC3 and may also play a role in Simpson-Golabi-Behmel syndrome.
免疫原
GPC4 (NP_001439, 30-66)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-term region of human GPC4.
生化/生理作用
GPC4 (glypican-4) is associated with a number of signaling mechanisms involving growth factors. GPC4 influences cell proliferation, by serving as a co-receptor for growth factors. It regulates the Wnt signaling pathway. GPC4 might be associated with epileptic seizures, with this gene upregulated in the brain. GPC4 is an adipokine and is known to enhance insulin signaling and regulate adipocyte differentiation. Overexpression of this gene in polycystic ovary syndrome might be associated with the risk of cardiovascular disease.
外形
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | saturated ammonium sulfate (SAS) precipitated |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| species reactivity | human |
| technique(s) | immunohistochemistry: 1:50-1:100 indirect ELISA: 1:1000 |
| NCBI登记号 | NP_001439 |
| UniProt登记号 | O75487 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | human ... GPC4(2239) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | nwg |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
