产品说明
一般描述
Many proteins are tethered to the extracellular face of eukaryotic plasma membranes by a glycosylphosphatidylinositol (GPI) anchor. The GPI-anchor is a glycolipid found on many blood cells. The protein encoded by this gene is a GPI degrading enzyme. Glycosylphosphatidylinositol specific phospholipase D1 hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans, thereby releasing the attached protein from the plasma membrane. (provided by RefSeq)
免疫原
GPLD1 (AAH20748.1, 1 a.a. ~ 176 a.a) full-length human protein.
Sequence
MSAFRLWPGLLIMLGSLCHRGSPCGLSTHIEIGHRALEFLQLHNGRVNYRELLLEHQDAYQAGIVFPDCFYPSICKGGKFHDVSESTHWTPFLNASVHYIRENYPLPWEKDTEKLVAFLFGITSHMAADVSWHSLGLEQGFLRTMGAIDFHGSYSEAHSAGDFGTVYLHLLNFLVV
应用
Anti-GPLD1 antibody produced in mouse is suitable for western blot analysis.
生化/生理作用
GPLD1 (Glycosylphosphatidylinositol specific phospholipase D1) is only expressed in human lver. Inositol phosphate linkage in proteins anchored by phosphatidylinositol-glycans (PI-Gs) is specifically hydrolyzed by GPLD1, suggesting GPLD1 expression might influence the location and expression of PI-G-anchored proteins. Studies have reported that it might be a significant factor in process of leukemia pathogenesis.
外形
Solution in phosphate buffered saline, pH 7.4
基本信息
| NACRES | NA.41 |
产品性质
| 质量水平 | 100 |
| 生物来源 | mouse |
| 偶联物 | unconjugated |
| 抗体形式 | purified immunoglobulin |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | antigen ~19.9 kDa |
| species reactivity | human |
| technique(s) | western blot: 1 μg/mL |
| NCBI登记号 | BC020748.1 |
| UniProt登记号 | P80108 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | human ... GPLD1(2822) |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
