产品说明
一般描述
Metabotropic glutamate receptor 2 (MGLUR2/GRM2) with 872 amino acids, is encoded by the gene mapped to human chromosome 3. GRM2 belongs to the class c of G-protein-coupled receptor (GPCRs) family. It is expressed mainly in the central nervous system (CNS) of rat brain and widely expressed in human adult and fetal brain. GRM2 is characterized with an α-helical helix 8 (H8) domain.
Anti-GRM2 Antibody detects endogenous levels of total GRM2 protein.
免疫原
The antiserum was produced against synthesized peptide derived from human GRM2.
Immunogen Range: 241-290
生化/生理作用
Metabotropic glutamate receptor (MGLUR2) is involved in the glutamatergic system in the brain. Overexpression of glutamate in brain areas such as the prefrontal cortex, hippocampus and amygdala leads to anxiety and schizophrenia, activation of MGLUR2 in these areas reduces the excitatory neurotransmission, therefore mGlu2 receptor might be considered as a potential target for the treatment of these diseases. GRM2 signaling inhibits adenylyl cyclase (AC) activity. GRM2 is required for the modulation of synaptic transmission.
特点和优势
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外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | antigen 95 kDa |
| species reactivity | human, rat, mouse |
| 浓度 | ~1 mg/mL |
| technique(s) | ELISA: 1:1000 immunofluorescence: 1:100-1:500 immunohistochemistry: 1:50-1:100 |
| NCBI登记号 | Q14416 |
| UniProt登记号 | Q14416 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... GRM2(2912) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | nwg |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
