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位置:首页 > 品牌 > Sigma-Aldrich > Anti-Heterochromatin Protein-1 α Antibody, clone 2HP-1H5

Anti-Heterochromatin Protein-1 α Antibody, clone 2HP-1H5

品牌
Sigma-Aldrich
货号
MAB3584
规格纯度
ascites fluid, clone 2HP-1H5, Chemicon®
参考价格
8874.93 *本价格含增值税费
促销
服务
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  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-Heterochromatin Protein-1 α Antibody, clone 2HP-1H5
HP1a, Antigen p25, Chromobox Protein Homolog 5
产品介绍:

产品说明

一般描述

Chromatin assembly factor-1 (CAF-1) is a multisubunit protein complex that comprises three polypeptide subunits known as p150, p60, and p48. CAF-1 is a nucleosome assembly factor that deposits newly synthesized and acetylated histones H3/H4 into nascent chromatin during DNA replication.

Heterochromatin is characterized as densely coiled chromatin that generally replicates late during S phase, has a low gene density, and contains large blocks of repetitive DNA that is relatively inaccessible to DNA-modifying reagents. In late S phase, p150 directly associates with heterochromatin associated proteins 1 (HP1α, HP1β and HP1γ). As cells prepare for mitosis, CAF-1 p150 and some HP1 progressively dissociate from heterochromatin, coinciding with the phosphorylation of histone H3. The HP1 proteins reassociate with chromatin at the end of mitosis, as histone H3 is dephosphorylated.

特异性

Reacts with Heterochromatin protein-1 alpha (HP1alpha) between amino acids 67 and 119.

免疫原

Recombinant mouse HP1a.

应用

Use Anti-Heterochromatin Protein-1 α Antibody, clone 2HP-1H5 (mouse monoclonal antibody) validated in ELISA, ICC, IHC to detect Heterochromatin Protein-1 α also known as HP1a, Antigen p25, Chromobox Protein Homolog 5.
Immunocytochemistry: 1:500-1:5,000

Immunohistochemistry: 1:500-1:5,000

ELISA: 1:500-1:5,000

Western blot: not recommended. For Western blot use MAB3446.

Optimal working dilutions must be determined by the end user.

外形

Unpurified
Liquid ascites no preservative.

分析说明

Control
Positive Control: HeLa cells, 3T3 cells , F9 cells, mouse embryos

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

法律信息

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss32160702
NACRESNA.41

产品性质

质量水平100
生物来源mouse
抗体形式ascites fluid
antibody product typeprimary antibodies
克隆2HP-1H5, monoclonal
species reactivityhuman, mouse
manufacturer/tradenameChemicon®
technique(s)ELISA: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable
同位素/亚型IgG1κ
适用性not suitable for Western blot
NCBI登记号NM_012117.1
UniProt登记号P45973
运输dry ice
Gene Informationhuman ... CBX5(23468)

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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