Anti-HSP70 antibody produced in rabbit

产品说明

一般描述

Heat Shock Proteins 70 (HSP70), also known as HSPA1A (heat shock protein family A (Hsp70) member 1A) or HSPA1B (heat shock protein family A (Hsp70) member 1B) is encoded by the gene mapped to human chromosome 6p21.3. xHSP70 is a highly conserved protein family with four members such as the constitutive (or cognate) HSP73, the stress-inducible HSP72, the glucose regulated proteins (grp)78 and grp75. During heat shock, HSP70s concentrate in the cell nuclei and return to the cytoplasm when the shock is removed.

免疫原

Synthetic peptide from the internal region of human HSP70 protein, conjugated to KLH

应用

The antibody has been used in various immunochemical techniques including immunoblotting (∼70 kDa) and immunoprecipitation.Detection of the HSP70 band by Immunoblotting is specifically inhibited by the immunogen.

生化/生理作用

Heat Shock Proteins 70 (HSP70) plays a key role in stress response, including heat stress, in every organism in which the proteins have been examined. These proteins also facilitates a wide range of folding processes, including the folding and assembly of newly synthesized proteins, refolding of misfolded and aggregated proteins, membrane translocation of organellar and secretory proteins, and control of the activity of regulatory proteins. In addition, HSP70 also play a cytoprotective role in neurodegenerative diseases such as Alzheimer′s, Parkinson′s, Huntington′s, ALS and others. Unregulated expression of HSP70s leads to the development of several types of cancer, such as malignant melanoma and renal cell cancer.

外形

Supplied as a solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide as a preservative.

其他说明

This product is for R&D use only, not for drug, household, or other uses.

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