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Anti-Human IgM (μ-chain specific) antibody, Mouse monoclonal

品牌
Sigma-Aldrich
货号
SAB4200780
规格纯度
clone MB-11, purified from hybridoma cell culture
参考价格
6564.11 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-Human IgM (μ-chain specific) antibody, Mouse monoclonal
Anti-Human immunoglobulin M
产品介绍:

产品说明

一般描述

Immunoglobulin M (IgM) is the major class of surface immunoglobulins on lymphocyte membranes. IgM is suggested to act as the first line of defense during microbial infections. IgM has a pentameric structure, in which monomers are linking together via disulfide bonds. Surface IgM is expressed on immature and mature B cells, whereas IgM heavy chain is expressed intracellularly in pre-B cells. IgM serves as the antigen receptor of naive B cells and is involved in B cell maturation and complement activation.
Anti-Human IgM (m-chain specific) antibody, Mouse monoclonal (mouse IgG2b isotype) is derived from the MB-11 hybridoma, produced by the fusion of mouse myeloma cells and splenocytes from a mouse immunized with purified human IgM protein.

特异性

Anti-Human IgM (m-chain specific) antibody, Mouse monoclonal specifically recognizes m chain of Human IgM. The antibody shows no cross-reactivity with human IgG, Fab, Fc, k, l, and g chains.

免疫原

Purified human IgM

应用

The antibody is recommended to use in various immunological techniques, including ELISA and Immunoblot.

生化/生理作用

Immunoglobulin M (IgM) acts as an antigen specific part of the B cell antigen receptor on the surface of B lymphocytes that are not stimulated, in its monomeric form. Polymeric IgM molecules also serve as important activators of the classical complement cascade. IgM is essential in agglutination and cytolytic reactions. IgM serves as the antigen receptor of naive B cells and is involved in B cell maturation and complement activation.

外形

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide as a preservative.

其他说明

This product is for R&D use only, not for drug, household, or other uses.

基本信息

NACRESNA.46

产品性质

质量水平300
生物来源mouse
抗体形式purified from hybridoma cell culture
antibody product typeprimary antibodies
克隆MB-11, monoclonal
形式buffered aqueous solution
species reactivityhuman
浓度~1.0 mg/mL
technique(s)ELISA: 0.1-0.2 μg/mL using 2.5 μg/mL Human IgM myeloma for coating
immunoblotting: suitable
同位素/亚型IgG2b
运输dry ice
储存温度−20℃

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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