Anti-IGFBP6 antibody produced in rabbit

产品说明

免疫原

Insulin-like growth factor-binding protein 6 precursor recombinant protein epitope signature tag (PrEST)

应用

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.

生化/生理作用

IGFBP6 (insulin-like growth factor binding protein 6) gene encodes a member of the IGF binding proteins (IGFBPs) that function in cell growth and differentiation. IGFBP6 differs from other members of the family in terms of its strong affinity to IGF-II over IGF-I. Human IGFBP6 does not contain 2 and 4 N-terminal cysteines, but has five serine/threonine glycosylation sites in the non-conserved mid-region. Human IGFBP6 is O-glycosylated and this glycosylation inhibits the proteolysis of IGFBP-6 by chymotrypsin and trypsin. Its main biological role is to regulate the activity of IGF-II, a factor implicated as an autocrine tumor growth factor. IGFBP-6 is associated with inhibition of tumor cell growth. This protein is found to be down-regulated in desmoid tumors by β-catenin. It regulates the expression of EGR (Early growth response)-1 and functions as an oncosuppressor in the pathogenesis of Nasopharyngeal carcinoma (NPC).

特点和优势

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

联系

Corresponding Antigen APREST86674.

外形

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

法律信息

Prestige Antibodies is a registered trademark of sigma-aldrich Co. LLC

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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