产品说明
一般描述
Anti-IL6 high-affinity antibody, mouse monoclonal (mouse IgG1 isotype) is derived from the IL6-4G1 hybridoma, produced by the fusion of mouse NS1 myeloma cells and splenocytes from a BALB/c mouse. Interleukin-6 (IL6) is mapped on the human chromosome at 7p15.3.
特异性
Monoclonal Anti-IL6 specifically recognizes human IL6 (KD ~4 x 10-11 M as measured by the Biacore system).
免疫原
recombinant human IL6
应用
Anti-IL6 high-affinity antibody, mouse monoclonal may be used in:
生化/生理作用
Interleukin-6 (IL6) is a multifunctional cytokine that plays a wide variety of biological roles in numerous systems including the immune, nervous and endocrine systems. It is considered to perform as a primary regulator of acute and chronic inflammatory diseases. IL6 is an excellent target for clinical treatment against autoimmune disorders such as rheumatoid arthritis, juvenile idiopathic arthritis and Castleman′s disease. It is overexpressed in the pathogenesis of myeloma patients. IL6 might have elevated serum IL6 levels in patients with different kinds of malignant disease. IL6 at higher levels are also clinically implemented as biomarkers for acute coronary syndrome (ACS) , unstable angina, cardiovascular disease, heart attack and stroke.
外形
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
储存及稳定性
For continuous use, store at 2–8 ℃ for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
免责声明
Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 质量水平 | 200 |
| 生物来源 | mouse |
| 抗体形式 | purified from hybridoma cell culture |
| antibody product type | primary antibodies |
| 克隆 | IL6-4G1, monoclonal |
| 形式 | buffered aqueous solution |
| species reactivity | human |
| 浓度 | ~1.0 mg/mL |
| technique(s) | ELISA: suitable immunoblotting: 2-4 μg/mL using concentrated supernatant of human osteosarcoma MG-63 cells treated with IL1β immunoprecipitation (IP): 1-2 μg/test using concentrated supernatant of human osteosarcoma MG-63 cells treated with IL1β |
| 同位素/亚型 | IgG1 |
| UniProt登记号 | P05231 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | human ... IL6(3569) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
