Anti-IL-31 Antibody

产品说明

一般描述

Interleukin-31 (IL-31) is a T-cell cytokine that activates STAT3 and possibly STAT1 and STAT5 through the IL-31 heterodimeric receptor composed of IL31RA and OSMR. IL-31 is similar to IL-6 type cytokines and is produced mainly by T helper type 2 cells. The ligand-induced oligomerization of a dimeric receptor complex containing IL-31 receptor A and oncostatin M receptor is the mediator of IL-31 activity. These proteins activate the JAK/STAT and the AKT signaling pathways in response to IL-31 binding. RNA levels of IL-31 receptor A and oncostatin M receptor are induced in activated monocytes and expressed highly in epithelial cells. Overexpression of IL-31 in transgenic mice results in the development of pruritis, alopecia, and skin lesions. Mutations of IL-31 in humans may result in atopic dermatitis, suggesting that IL-31 may play a role in skin immunity and may represent a novel target for antipruritic drug development.

特异性

This antibody recognizes the N-terminus of IL-31.

免疫原

Epitope: N-terminus
KLH-conjugated linear peptide corresponding to the N-terminus of human IL-31.

应用

Immunohistochemistry Analysis: 10 µg/mL from a representative lot detected IL-31 in rat skeletal muscle tissue.
Anti-IL-31 Antibody is a highly specific rabbit polyclonal antibody, that targets IL-31 & has been tested in western blotting & IHC.
Research Category
Signaling
Research Sub Category
Developmental Signaling

质量

Evaluated by Western Blotting in RAW264.7 cell lysate.

Western Blotting Analysis: 2.5 µg/mL of this antibody detected IL-31 in 15 µg of RAW264.7 cell lysate.

目标描述

~30 kDa observed. Uncharacterized bands may appear in some lysate(s).

外形

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
Antigen Affinity Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

分析说明

Control
RAW264.7 cell lysate

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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