产品说明
一般描述
Insulin gene enhancer binding protein-1 (ISL-1) gene spanning 220kb of genomic DNA, is mapped to human chromosome 5q11.1. The gene codes for a member of LIM zinc-binding/homeobox-domain transcription factor and is predominantly expressed in hindbrain, forebrain, ventral neural tube, dorsal root ganglia (DRG) and trigeminal ganglia.
免疫原
ISL1 (NP_002193, 63 a.a. ~ 159 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
YCKRDYIRLYGIKCAKCSIGFSKNDFVMRARSKVYHIECFRCVACSRQLIPGDEFALREDGLFCRADHDVVERASLGAGDPLSPLHPARPLQMAAEP
生化/生理作用
Insulin gene enhancer binding protein-1 (ISL-1) is a transcription factor which plays a vital role in the development of the heart, motor neurons and pancreas. It also stimulates adult pancreatic ß-cells proliferation. ISL1 might also be involved in the regulation of insulin expression. Elevated expression of the gene has been observed in patients with gastric cancer. Thus, the protein can be used as a potential biomarker and therapeutic target for gastric cancer. Mutation in the gene is associated with the increased risk of susceptibility to human congenital heart disease (CHD).
外形
Solution in phosphate buffered saline, pH 7.4
基本信息
| NACRES | NA.41 |
产品性质
| 质量水平 | 100 |
| 生物来源 | mouse |
| 偶联物 | unconjugated |
| 抗体形式 | purified immunoglobulin |
| antibody product type | primary antibodies |
| 克隆 | 8A3, monoclonal |
| 形式 | buffered aqueous solution |
| 分子量 | antigen 36.41 kDa |
| species reactivity | human |
| technique(s) | indirect ELISA: suitable indirect immunofluorescence: suitable western blot: 1-5 μg/mL |
| 同位素/亚型 | IgG2aκ |
| NCBI登记号 | NM_002202 |
| UniProt登记号 | P61371 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | human ... ISL1(3670) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
