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Anti-JAM-A antibody, Mouse monoclonal

品牌
Sigma-Aldrich
货号
SAB4200468
规格纯度
clone J10.4, purified from hybridoma cell culture
参考价格
6750.02 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-JAM-A antibody, Mouse monoclonal
Monoclonal Anti-JAM1
Monoclonal Anti-JAMA
Monoclonal Anti-CD321
Monoclonal Anti-F11 receptor
Monoclonal Anti-KAT
Monoclonal Anti-F11R
Monoclonal Anti-JCAM
Monoclonal Anti-JAM
Monoclonal Anti-PAM-1
产品介绍:

产品说明

一般描述

Anti-JAM-A antibody, Mouse monoclonal, (mouse IgG1 isotype) is derived from the hybridoma J10.4 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a recombinant human JAM. Junctional adhesion molecule A (JAM-A) is expressed at tight junctions of endothelial and epithelial cells as well as on a variety of hematopoietic cells. It belongs to the transmembrane IgG glycoprotein family and is also expressed in monocytes, lymphocytes, neutrophils, dendritic cells, platelets, and spermatozoa. The JAM-A or F11R gene is mapped to human chromosome 1q23.3.

特异性

Anti-JAM-A antibody, Mouse monoclonal recognizes human JAM-A.

免疫原

derived from the hybridoma J10.4 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a recombinant human JAM fusion protein.

应用

Anti-JAM-A antibody, Mouse monoclonal has been used in:

  • western blotting
  • staining for confocal microscopy
  • immunoprecipitation
  • immunocytochemistry
  • flow cytometry

生化/生理作用

Junctional adhesion molecule A(JAM-A) function has been linked with regulation of cell migration/invasion, platelet adhesion, cell polarity, cell proliferation, and epithelial or endothelial barrier function. However, the mechanisms by which JAM-A mediates these processes have not been well elucidated. JAM-A functional significance is connected with inflammation, angiogenesis, hypertension, ischemia/reperfusion, and atherosclerosis. JAM-A has also been linked to breast, endometrial, renal cell carcinomas and gastric cancer.

外形

0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。

储存及稳定性

For extended storage, freeze at –20 ℃ in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.41

产品性质

质量水平200
生物来源mouse
偶联物unconjugated
抗体形式purified immunoglobulin
antibody product typeprimary antibodies
克隆J10.4, monoclonal
形式buffered aqueous solution
分子量antigen 37 kDa
species reactivityhuman
浓度~1.0 mg/mL
technique(s)immunoblotting: 1.0-2.0 μg/mL using HepG2 or A431 or A549 total cell extracts
同位素/亚型IgG1
UniProt登记号Q9Y624
运输dry ice
储存温度−20℃
Gene Informationhuman ... F11R(50848)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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