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Anti-KCNC4 antibody produced in rabbit

品牌
Sigma-Aldrich
货号
HPA014740
规格纯度
Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
参考价格
6389.73 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-KCNC4 antibody produced in rabbit
Anti-Potassium voltage-gated channel subfamily C member 4
Anti-Voltage-gated potassium channel subunit Kv34
Anti-KSHIIIC
产品介绍:

产品说明

一般描述

KCNC4 (potassium channel, voltage gated Shaw related subfamily C, member 4) is an A-type K+ channel, and is also called Kv3.4. Its inactivation gate is made by the first 28 amino acids present in the N-terminal. This inactivation sequence also contains four predicted protein kinase C (PKC) phosphorylation sites. It is expressed in muscle, spinal cord, dorsal root ganglia, mossy fiber neurons and Purkinje neurons.

免疫原

Potassium voltage-gated channel subfamily C member 4 recombinant protein epitope signature tag (PrEST)

应用

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.

生化/生理作用

KCNC4 (potassium channel, voltage gated Shaw related subfamily C, member 4) is suppressed by protein kinase C by N-type inactivation, in dorsal root ganglia neurons. This results in regulation of the duration of action potential, as well as the rate of repolarization. Any aberration leads to loss of homeostasis, which is seen in chronic pain conditions post spinal cord injury. Ionizing radiation leads to the activation of this channel, which results in cell cycle arrest in G2/M phase, as seen in irradiated leukemia cells. This channel is up-regulated in head and neck squamous cell carcinomas, where it facilitates tumorigenesis and malignancy. In vitro studies show that under the influence of estrogen, KCNC4 regulates the development and remodeling of arteries in human uterus, during pregnancy. It is up-regulated in early stages of Alzheimer′s disease (AD), and is found highly abundant at later stages of the disease, in neurodegenerative regions.

特点和优势

Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

  • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
  • Protein array of 364 human recombinant protein fragments.

联系

Corresponding Antigen APREST73041.

外形

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

法律信息

Prestige Antibodies is a registered trademark of sigma-aldrich Co. LLC

基本信息

人类蛋白质图谱编号HPA014740    Human Protein Atlas characterization data

产品性质

生物来源rabbit
质量水平100
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
产品线Prestige Antibodies® Powered by Atlas Antibodies
形式buffered aqueous glycerol solution
species reactivityhuman
包装antibody small pack of 25 μL
technique(s)immunofluorescence: 0.25-2 μg/mL
免疫原序列ISSVCVSSYRGRKSGNKPPSKTCLKEEMAKGEASEKIIINVGGTRHETYRSTLRTLPGTRLAWLADPD
UniProt登记号Q03721
运输wet ice
储存温度−20℃
Gene Informationhuman ... KCNC4(3749)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Sigma-Aldrich

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