Anti-KIAA1706 antibody produced in mouse

产品说明

一般描述

KIAA1706 is also known as endonuclease-exonuclease-phosphatase family domain containing 1 (EEPD1). The gene is located on human chromosome 7p14.2. This gene contains two helix−hairpin−helix motifs at the N-terminal and an exonuclease/endonuclease/phosphatase domain at the C-terminal end. The protein is localized in the plasma membrane with a myristoylation site in its N terminus.

免疫原

KIAA1706 (AAH65518.1, 1 a.a. ~ 569 a.a) full-length human protein.

Sequence
MGSTLGCHRSIPRDPSDLSHSRKFSAACNFSNILVNQERLNINTATEEELMTLPGVTRAVARSIVEYREYIGGFKKVEDLALVSGVGATKLEQVKFEICVSSKGSSAQHSPSSLRRDLLAEQQPHHLATAVPLTPRVNINTATPAQLMSVRGLSEKMALSIVDFRREHGPFRSVEDLVRMDGINAAFLDRIRHQVFAERSRPPSTHTNGGLTFTAKPHPSPTSLSLQSEDLDLPPGGPTQIISTRPSVEAFGGTRDGRPVLRLATWNLQGCSVEKANNPGVREVVCMTLLENSIKLLAVQELLDREALEKFCTELNQPTLPNIRKWKGPRGCWKAVVAEKPSNQLQKGAGYAGFLWDAAAGMELRDAGSQESSPSNGHGKLAGPSPYLGRFKVGSHDLTLVNLHLAALTLLGSENPSKNHSDGHRLASFAQTLQETLKGEKDVIILGDFGQGPDSNDYDILRKEKFHHLIPAHTFTNISTKNPQGSKSLDNIWISKSLKKVFTGHWAVVREGLTNPWIPDNWSWGGVASEHCPVLAEFYTEKDWSKKDAPRNGSGVALERSEANIKHER

生化/生理作用

Endonuclease-exonuclease-phosphatase family domain containing 1 (EEPD1), also known as KIAA1706, acts as a gatekeeper for the repair of stressed replication forks. It maintains the integrity of cell genome by developing safe homologous recombination fork repair pathway. Deficiency of this protein is associated with severe chromosomal abnormalities. The protein acts as a LXR-target gene, which maintains cholesterol efflux and activity of ATP-binding cassette transporter (ABCA1).

外形

Solution in phosphate buffered saline, pH 7.4

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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