产品说明
一般描述
Lamin A is encoded by the gene with exons 1–12, mapped on human chromosome 1q21-22. The encoded protein is a major component of the inner nuclear membrane lamina. Lamin A is expressed in variety of tissues, including adult heart and skeletal muscle.
免疫原
synthetic peptide corresponding to the C-terminus of mature human Lamin A.
应用
Monoclonal Anti-Lamin A, mature antibody produced in mouse has been used in immunohistochemistry.
生化/生理作用
Lamin A can be used as a biomarker for cancer diagnosis and prognosis. It also plays a major role in maintaining cardiac homeostasis. Mutation in the gene is associated with Emery-Dreifuss muscular dystrophy (EDMD-AD) and Hutchinson–Gilford progeria syndrome (HGPS). In addition, variation in the gene expression also leads to various disorders such as, lipodystrophy, progeria, muscular dystrophy, neuropathy and cardiomyopathy.
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 质量水平 | 200 |
| 生物来源 | mouse |
| 偶联物 | unconjugated |
| 抗体形式 | purified from hybridoma cell culture |
| antibody product type | primary antibodies |
| 克隆 | 4A4, monoclonal |
| 形式 | buffered aqueous solution |
| 分子量 | antigen ~72 kDa |
| species reactivity | human |
| 浓度 | ~1.0 mg/mL |
| technique(s) | indirect immunofluorescence: 0.25-0.5 μg/mL using human HeLa cells western blot: 0.25-0.5 μg/mL using whole extracts of human HeLa cells |
| 同位素/亚型 | IgG1 |
| UniProt登记号 | P02545 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | human ... LMNA(4000) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
