Anti-LEMD3 Antibody

产品说明

一般描述

LEM domain-containing protein 3 (LEMD3), also known as Inner nuclear membrane protein Man1 (MAN1), is an inner nuclear membrane protein that interacts with BMP and activin-TGF-beta receptor-activated Smads and antagonizes TGF-beta signaling in human cells. Additionally, LEMD3 is shown to Interact with SMAD1, SMAD2, SMAD3 and SMAD5. Studies also show that LEMD3 binds to both the phosphorylated and the unphosphorylated R-SMADS. LEMD3 is expressed in heart, brain, placenta, lung, liver and skeletal muscle. Defects in LEMD3 are shown to cause disorders, such as osteopoikilosis, Buschke-Ollendorff syndrome (BOS), and melorheostosis (MEL).

免疫原

KLH-conjugated linear peptide corresponding to human LEMD3.

应用

Anti-LEMD3 Antibody is a highly specific rabbit polyclonal antibody, that targets LEM domain-containing protein 3 & has been tested in western blotting & IHC.
Research Category
Signaling
Research Sub Category
Developmental Signaling
Immunohistochemistry Analysis: 2.5 µg/mL from a representative lot detected LEMD3 in human colon tissue.

质量

Evaluated by Western Blotting in human colon tissue lysate.

Western Blotting Analysis: 1 µg/mL of this antibody detected LEMD3 in 15 µg of human colon tissue lysate.

目标描述

~120 kDa observed. Uncharacterized bands may appear in some lysate(s).

外形

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
Antigen Affinity Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

分析说明

Control
Human colon tissue lysate

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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