产品说明
一般描述
The Lin28 (lin-28 homolog A) gene encodes RNA-binding protein, and is located on human chromosome 1p36.
The antibody detects endogenous levels of total Lin28 protein.
免疫原
Peptide sequence around aa. 1-5 (M-G-S-V-S), according to the protein NP_078950.1
生化/生理作用
The Lin28 (lin-28 homolog A) protein participates in several biological processes like development, reprogramming, differentiation, pluripotency and glucose metabolism.{19, 20} It plays an important role in immunity.
特点和优势
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目标描述
Acts as a ′translational enhancer′, driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression. Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 in embryonic stem (ES) cells contributes to the maintenance of ES cells.
外形
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | ~26 kDa |
| species reactivity | mouse, human, rat |
| 浓度 | 1 mg/mL |
| technique(s) | western blot: 1:500-1:1000 |
| 同位素/亚型 | IgG |
| 免疫原序列 | (M-G-S-V-S) |
| NCBI登记号 | NM_024674.4 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... Lin28(79727) |
安全信息
| 储存分类代码 | 10 - Combustible liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
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